Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis / Masato Okano, Mario Thevis, Mitsuhiko Sato, Shinji Kageyama
- Drug Testing And Analysis 8 (2016) 8 (August), p. 869-874
- PMID: 26560081
- DOI: 10.1002/dta.1893
Abstract
The identification of trimetazidine in urine samples might result from administration of the permitted drug lomerizine. Laboratories are therefore urged to carefully investigate suspicious cases where trimetazidine is detected. Differentiation of abuse of the banned substance trimetazidine from use of the permitted drug lomerizine would be supported by analysis of the intact drug lomerizine and/or specific metabolites.
