Annual banned-substance review: analytical approaches in human sports drug testing / Mario Thevis, Tiia Kuuranne, Hans Geyer, Wolhelm Schänzer. - (Drug testing and analysis 9 (2017) 1 (January) : p. 6-29)
- PMID: 27885819
- DOI: 10.1002/dta.2139
Contents:
- Introduction
- Non-approved substances
- Anabolic agents
- Anabolic-androgenic steroids
- Iitial testing procedures – multi-analyte screening methods and alternative chromatographic- mass spectrometric techniques
- Initial testing procedures – metabolism studies and new target analytes
- Steroid profiling
- Alternative test methods and approaches
- Other anabolic agents
- Peptide hormones, growth factors and related subsances
- Hyoxia-iducible factor stabilizers and activators
- Growth hormone
- Corticotrophins, insulin-like growth factor-1 (IGF-1), and other growth or releasing factors
- Beta-2-agonists
- Hormone and metabolic modulators
- Diuretics and other masking agents
- Stimulants
- Narcotics and glucocorticoids
- Manipulation of blood and blood components
- Chemical and physical manipulation
- Gene doping
- Conclusion
- References
Abstract
There has been an immense amount of visibility of doping issues on the international stage over the past 12 months with the complexity of doping controls reiterated on various occasions. Hence, analytical test methods continuously being updated, expanded, and improved to provide specific, sensitive, and comprehensive test results in line with the World Anti-Doping Agency's (WADA) 2016 Prohibited List represent one of several critical cornerstones of doping controls. This enterprise necessitates expediting the (combined) exploitation of newly generated information on novel and/or superior target analytes for sports drug testing assays, drug elimination profiles, alternative test matrices, and recent advances in instrumental developments. This paper is a continuation of the series of annual banned-substance reviews appraising the literature published between October 2015 and September 2016 concerning human sports drug testing in the context of WADA's 2016 Prohibited List.
