Drug Testing and Analysis Early View, Article first published online: 12 JUL 2012
Ying Zhang, Ross M. Woods, Zachary S. Breitbach and Daniel W. Armstrong
1,3-Dimethylamylamine (DMAA) is a stimulant existing in various pre-workout supplements and often labelled as part of geranium
plants. The safety and origin of DMAA in these supplements is the subject of intense debate. In this study, the enantiomeric
and diastereomeric ratios of two different known synthetic DMAA compounds, as well as the total concentrations of DMAA and its
stereoisomeric ratios in 13 different supplements,were determined by gas chromatography. The stereoisomeric ratios of DMAA in
the synthetic standards and in all the commercial supplements were indistinguishable. Eight different commercial geranium
extracts of different geographical origins (China and the Middle East) were examined for the presence of DMAA by high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). No DMAA was detected in any of the eight geranium products with a limit of detection of 10 parts per billion (w/w).