Annual banned-substance review: analytical approaches in human sports drug testing - [2017-2018]

Annual banned-substance review: Analytical approaches in human sports drug testing / Mario Thevis, Tiia Kuuranne, Hans Geyer. - (Drug Testing and Analysis 11 (2019) 1 (January; p. 8-26)

  • PMID: 30488582
  • DOI: 10.1002/dta.2549


  • Introduction
  • Non-Approved Substances
  • Anabolic Agents
    • Anabolic-androgenic steroids
    • Initial testing procedures: Comprehensive screening, metabolism studies, and new target analytes
    • Steroid profiling
    • Confirmatory testing procedures – IRMS
    • Other anabolic agents
  • Peptide Hormones, Growth Factors, Related Substances, and Mimetics
    • Erythropoietin-receptor agonists
    • Hypoxia-inducible factor stabilizers and activators
    • Transforming growth factor-beta (TGR- β) inhibitors
    • Growth hormone, its fragments and releasing factors, and chorionic gonadotrophin
  •  β2‐Agonists
  • Hormone and Metabolic Modulators
  • Diuretics and other Masking Agents, Stimulants, Narcotics, and Glucocorticoids
  • Chemical and Physical Manipulation / Gene Doping
  • Monitoring Program
  • Conclusion


A number of high profile revelations concerning anti‐doping rule violations over the past 12 months have outlined the importance of tackling prevailing challenges and reducing the limitations of the current anti‐doping system. At this time, the necessity to enhance, expand, and improve analytical test methods in response to the substances outlined in the World Anti‐Doping Agency (WADA) Prohibited List represents an increasingly crucial task for modern sports drug testing programs. The ability to improve analytical testing methods often relies on the expedient application of novel information regarding superior target analytes for sports drug testing assays, drug elimination profiles, and alternative sample matrices, together with recent advances in instrumental developments. This annual banned‐substance review evaluates literature published between October 2017 and September 2018 offering an in‐depth evaluation of developments in these arenas and their potential application to substances reported in WADA's 2018 Prohibited List.

Original document


18 November 2018
Geyer, Hans
Kuuranne, Tiia
Thevis, Mario
Legal Terms
WADA Code, Guidelines, Protocols, Rules & Regulations
WADA Prohibited List International Standard
Other organisations
Centre Hospitalier Universitaire Vaudois (CHUV) - Lausanne University Hospital
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
European Monitoring Center for Emerging Doping Agents (EuMoCEDA)
Cologne, Germany: Institute of Biochemistry - German Sport University Cologne
Lausanne, Switzerland: Laboratoire Suisse d’Analyse du Dopage
Analytical aspects
Mass spectrometry analysis
Testing method development
Doping classes
M1. Manipulation Of Blood And Blood Components
M2. Chemical And Physical Manipulation
M3. Gene And Cell Doping
P1. Beta-Blockers
S0. Non-Approved Substances
S1. Anabolic Agents
S2. Peptide Hormones, Growth Factors
S3. Beta-2 Agonists
S4. Hormone And Metabolic Modulators
S5. Diuretics and Other Masking Agents
S6. Stimulants
S7. Narcotics
S9. Glucocorticosteroids
Medical terms
Substance use research
Doping control
Document category
Scientific article
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Pdf file
Date generated
4 July 2019
Date of last modification
23 November 2022
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